Group A
| Rank | Teams | Played | Won | Drawn | Lost | Differential | Goal difference | Points | Current form |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
 Lyon |
6 | 5 | 1 | 0 | 16 - 5 | 11 | 16 | DWDDL |
| 2 |
 Rangers |
6 | 2 | 2 | 2 | 6 - 5 | 1 | 8 | LWLWD |
| 3 |
 Sparta Praha |
6 | 2 | 1 | 3 | 6 - 9 | -3 | 7 | WLLLW |
| 4 |
 Brøndby IF |
6 | 0 | 2 | 4 | 2 - 11 | -9 | 2 | LLDLL |
Group B
| Rank | Teams | Played | Won | Drawn | Lost | Differential | Goal difference | Points | Current form |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
 Monaco |
6 | 3 | 3 | 0 | 7 - 4 | 3 | 12 | DWDLD |
| 2 |
 Real Sociedad |
6 | 2 | 3 | 1 | 9 - 6 | 3 | 9 | DLWDL |
| 3 |
 PSV |
6 | 2 | 2 | 2 | 9 - 8 | 1 | 8 | WLDWL |
| 4 |
 Sturm Graz |
6 | 0 | 2 | 4 | 3 - 10 | -7 | 2 | LLDLD |
Group C
| Rank | Teams | Played | Won | Drawn | Lost | Differential | Goal difference | Points | Current form |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
 Spartak Moscow |
6 | 3 | 1 | 2 | 10 - 9 | 1 | 10 | WLDWW |
| 2 |
 Napoli |
6 | 3 | 1 | 2 | 15 - 10 | 5 | 10 | WLWDL |
| 3 |
 Leicester |
6 | 2 | 2 | 2 | 12 - 11 | 1 | 8 | LWDWL |
| 4 |
 Legia Warsaw |
6 | 2 | 0 | 4 | 4 - 11 | -7 | 6 | WLLLL |
Group D
| Rank | Teams | Played | Won | Drawn | Lost | Differential | Goal difference | Points | Current form |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
 Frankfurt |
6 | 3 | 3 | 0 | 10 - 6 | 4 | 12 | DWWWD |
| 2 |
 Olympiacos |
6 | 3 | 0 | 3 | 8 - 7 | 1 | 9 | LWLLL |
| 3 |
 Fenerbahçe |
6 | 1 | 3 | 2 | 7 - 8 | -1 | 6 | LDWLD |
| 4 |
 Antwerp |
6 | 1 | 2 | 3 | 6 - 10 | -4 | 5 | LDLDW |
Group E
| Rank | Teams | Played | Won | Drawn | Lost | Differential | Goal difference | Points | Current form |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
 Galatasaray |
6 | 3 | 3 | 0 | 7 - 3 | 4 | 12 | DWDDL |
| 2 |
 Lazio |
6 | 2 | 3 | 1 | 7 - 3 | 4 | 9 | DWDLD |
| 3 |
 Marseille |
6 | 1 | 4 | 1 | 6 - 7 | -1 | 7 | DDDLW |
| 4 |
 Lokomotiv |
6 | 0 | 2 | 4 | 2 - 9 | -7 | 2 | LLDLL |
Group F
| Rank | Teams | Played | Won | Drawn | Lost | Differential | Goal difference | Points | Current form |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
 Crvena zvezda |
6 | 3 | 2 | 1 | 6 - 4 | 2 | 11 | LWDLW |
| 2 |
 Braga |
6 | 3 | 1 | 2 | 12 - 9 | 3 | 10 | WWDWL |
| 3 |
 Midtjylland |
6 | 2 | 3 | 1 | 7 - 7 | 0 | 9 | LDWWD |
| 4 |
 Ludogorets |
6 | 0 | 2 | 4 | 3 - 8 | -5 | 2 | LLLLD |
Group G
| Rank | Teams | Played | Won | Drawn | Lost | Differential | Goal difference | Points | Current form |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
 Leverkusen |
6 | 4 | 1 | 1 | 14 - 5 | 9 | 13 | WWLLL |
| 2 |
 Betis |
6 | 3 | 1 | 2 | 12 - 12 | 0 | 10 | LWDLD |
| 3 |
 Celtic |
6 | 3 | 0 | 3 | 13 - 15 | -2 | 9 | LWWLW |
| 4 |
 Ferencvárosi |
6 | 1 | 0 | 5 | 5 - 12 | -7 | 3 | LLLLW |
Group H
| Rank | Teams | Played | Won | Drawn | Lost | Differential | Goal difference | Points | Current form |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
 West Ham |
6 | 4 | 1 | 1 | 11 - 3 | 8 | 13 | WDWLL |
| 2 |
 Dinamo Zagreb |
6 | 3 | 1 | 2 | 9 - 6 | 3 | 10 | WDWLW |
| 3 |
 Rapid Wien |
6 | 2 | 0 | 4 | 4 - 9 | -5 | 6 | LWLLW |
| 4 |
 Genk |
6 | 1 | 2 | 3 | 4 - 10 | -6 | 5 | LLDDL |
Knockout
Preliminary knockout round
Transfer to Europa Conference League
1/16 Final
Thursday 17 February, 2022 15:00
1/8 Final
Thursday 10 March, 2022 15:00
1/4 Final
Thursday 14 April, 2022 12:45
1/2 Final
Final
Data by Statorium soccer API